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KMID : 0604219960030020131
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Korean Journal Investigative Dermatology
1996 Volume.3 No. 2 p.131 ~ p.137
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Influence of TGF-β and TNF-α on Type VII Collagen Gene
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Abstract
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Type Ⅶcollagen is the predominant component of the anchoring fibrils and both dermal fibroblasts and epidermal keratinocytes in culture synthesize typeⅦcollagen. The presence of anchoring fibrils is apparently critical for the stability of the
cutaneous basement membrane zone, because abnormalities in quantity or quality of anchoring fibrils manifest as dystrophic forms of epidermolysis bullosa(EB). But there is little known about effects of cytokines on type Ⅶ collagen gene
expression.
We
have examined the response of the fibroblasts and keratinocytes in type Ⅶcollagen gene expression to transforming growth factor-β(TGF-β) as well as tumor necrosis factor-α(TNF-α), which have been shown to modulate the expression of the
extracellular matrix genes using Northern blot hybridizations.
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